Failure to Confirm the Macrophage Electrophoretic Mobility Test in Cancer
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چکیده
منابع مشابه
The macrophage electrophoretic mobility test for malignancy.
Lymphocytes obtained from the blood of patients suffering from malignant disease liberate, when incubated with a basic protein obtained from carci nomatous tissue or the brain, a substance ( slowing factor ) which reduces the electrophoretic mobility of guinea pig macrophages. Lymphocytes from normal subjects or patients with non malignant tumors do not liberate this slowing factor. The macrop...
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The results of an assessment of the macrophage electrophoretic mobility test in cancer diagnosis are described. We found that the test did not reliably distinguish between a group of 18 patients with benign disorders and a group of 25 with malignant disease.
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The macrophage electrophoretic mobility (MEM) test of Field and Caspary did not clearly separate patients with ocular neoplastic disease from those with inflammatory disease, although there was some indication of discrimination between choroidal melanoma and ocular inflammation. In our hands the test failed to give a reproducible result for the immunodiagnosis of ocular malignancy. The techniqu...
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That mammalian cells migrate in an electrical field with differing speeds depending upon their surface charge has been known for some time (Ambrose, I965). This method of cell electrophoresis was first applied in experimental immunology by Sunderam, Phondke, and Ambrose (I967), who showed that the electrophoretic migration of peritoneal macrophages from a guinea-pig previously immunized with a ...
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The phenomenological model of Khossravi and Connors (1992) has been adopted to calculate the electrophoretic mobility of drugs at different concentrations of solvents in a binary mixture. The accuracy and predictability of the model have been evaluated employing 14 experimental data sets by using average percentage mean deviation (APMD). The obtained APMD for correlative and predictive studies ...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1977
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1977.228